DP22 Cutaneous lymphoid hyperplasia: clinicopathological correlation and a therapeutic option

Abstract Cutaneous reactive lymphoid hyperplasia, also known as cutaneous pseudolymphoma, is an uncommon entity in which there are skin lesions that histologically, and sometimes clinically, mimic lymphoma but not, both morphologically immunohistochemically. Correlating clinical, pathological, immunohistochemical and, occasionally, molecular findings essential for the diagnosis (Romero-Perez D, Blanes Martinez M, Encabo-Duran B. Pseudolinfomas cutaneous. Actas Dermosifiliogr 2016; 107:640–51). Although majority of cases can be regarded idiopathic, certain infections inflammatory conditions precipitate examples include Borrelia infection, insect bite reactions folliculitis (Mitteldorf, C, Kempf, W. pseudolymphoma – a review on spectrum proposal new classification. J Cutan Pathol 2020; 47:76–97). The first case was 18-year-old woman who presented with deep dermal subcutaneous nodules last 5 years started her limbs were slightly itchy. firm deep, minimal surface changes (hyperpigmentation adherent scale) did not ulcerate. She had involving buccal mucosa, inner lips soft tissue nasal bridge couple cheeks. Pathological examination showed dense lymphocytic infiltrate plasma cells admixed other dermis extension to dermal/subcutaneous junction. pathological picture tumid lupus/lupus panniculitis overlap hyperplasia. Immunohistochemical stains mixture CD3+ CD20+ cells. Lip mucosal biopsy florid follicular Her condition resistant multiple systemic treatments. Eventually, she underwent treatment rituximab satisfactory results. second patient elderly female erythematous papules, plaques face. periadnexal predilection follicles highlighted by CD20, Bcl2 around germinal centres. diagnosed having Topical calcineurin inhibitors initiated, good response. In conclusion, this paper highlights term pseudolymphoma/cutaneous presenting few clinicopathological correlation exploring some options.